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EC number: 947-528-6
CAS number: -
One valid experiment was performed.
Bovine corneas were used. They were collected from slaughtered cattle
which were between
12 and 60 months old.
The test item Bis(neodecanoyloxy)dioctylstannane was brought onto the
cornea of a bovine
eye which had been incubated with cMEM without phenol red at 32 ± 1 °C
for 1 hour
and whose opacity had been measured.
The test item was incubated on the cornea for 10 minutes at 32 ± 1 °C.
After removal of
the test item and 2 hours post-incubation, opacity and permeability
values were measured.
HBSS-solution was used as negative control. The negative control showed
effect on the cornea and the calculated IVIS (in vitro irritancy score)
Dimethylformamide (DMF) undiluted was used as positive control. The
positive control induced
serious eye damage on the cornea and falls within two standard
deviations of the
current historical mean. The calculated IVIS (in vitro irritancy score)
Under the conditions of this study, the test item
showed no effects on the cornea of the bovine eye. The calculated IVIS
(in vitro irritancy
score) is 2.13.
According to OECD Guideline no. 437 (Jul. 2013), a substance with an
IVIS ≤ 3 requires
no classification for eye irritation or serious eye damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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