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EC number: 947-528-6
CAS number: -
One valid experiment was performed.
Two tissues of the human skin model EpiDermTM were treated with the test
Bis(neodecanoyloxy)dioctylstannane for 3 minutes and 1 hour,
respectively. The test item
was applied to each tissue and spread to match the tissue size.
Demineralised water was used as negative control, 8 M KOH was used as
After treatment, the respective substance was rinsed from the tissues.
Then, cell viability of
the tissues was evaluated by addition of MTT, which can be reduced to a
Formazan production was evaluated by measuring the optical density (OD)
at 570 nm of the
After treatment with the negative control, the absorbance values were
within the required
acceptability criterion of mean OD ≥ 0.8 and ≤ 2.8 for both treatment
intervals thus showing
the quality of the tissues. The OD was 1.8 (3 minutes experiment) and
1.6 (1 hour experiment).
The positive control showed clear corrosive effects for both treatment
mean relative tissue viability value was reduced to 7.8 % after the 1
hour treatment (and
reduced to 19.5 % after the 3 min treatment).
After 3 minutes treatment with the test item, the mean value of relative
tissue viability was
reduced to 95.5 %. This value is above the threshold for corrosion
potential (50%). After 1
hour treatment, the mean value of relative tissue viability was
increased to 102.5 %. This
value, too, is above the threshold for corrosion potential (15%).
Therefore, Bis(neodecanoyloxy)dioctylstannane is considered
non-corrosive to skin in the Reconstructed Human Epidermis (RHE) Test
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