(R,R)-(-)-butane-2,3-diol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1979-04-18 - 1980-12-22

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Method: other: BASF test

GLP compliance:

no

Test type:

other: BASF test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Butane-2,3-diol

EC Number:

208-173-6

EC Name:

Butane-2,3-diol

Cas Number:

513-85-9

Molecular formula:

C4H10O2

IUPAC Name:

butane-2,3-diol

Test material form:

liquid

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

no mortality

Clinical signs:

other: Dyspnea, Apathy, Staggering, Piloerection, Erythema, Exophthalmos, Poor general state

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Based on the available data the substance showed no mortality up to 5000 mg/kg bw.

Executive summary:

Based on the available data the substance showed no mortality up to 5000 mg/kg bw. Clinical signs were dyspnoea, apathy, staggering, piloerection, erythema, exophthalmos, and a poor general state.