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EC number: 949-694-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial radical formation potential
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
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- Specific investigations
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 January 1992 - 04 February 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Standard acute oral toxicity method. The test substance was administered to rats by oral gavage at a single dose of 5000 mg/kg bw, and animals were monitored for 14 days.
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Magnesium potassium fluoride silicate (Mg2.7K0.7Si4O10F2)
- EC Number:
- 949-694-5
- Molecular formula:
- Mg2.7K0.7Si4O10F2
- IUPAC Name:
- Magnesium potassium fluoride silicate (Mg2.7K0.7Si4O10F2)
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- Nonswellable mica MK (Micromica), supplied by Co-op Chemical Co., Ltd.
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Sankyo Lab Service
- Age at study initiation: 4 weeks
- Weight at study initiation: 91.6 g (males)/81.2 g (females)
- Fasting period before study: 16 hours
- Housing: 5/sex in polycarbonate cages bedded with wood chips
- Diet (e.g. ad libitum): commercial diet ad libitum
- Water (e.g. ad libitum): drinking water ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 °C (± 2 °C)
- Humidity (%): 50% ± 10%
- Air changes (per hr): 17
- Photoperiod (hrs dark / hrs light): 12 hours (artificial light provided 0600 - 1800)
IN-LIFE DATES: Not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25% (w/v)
- Amount of vehicle (if gavage): 20 mL/kg
- Justification for choice of vehicle: standard vehicle - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Remarks:
- Vehicle only
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: once daily (in the morning)
- Necropsy of survivors performed: yes
- Other examinations performed: macroscopic examination of "organs" [not further specified] - Statistics:
- Not specified
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths were observed in any treated animals
- Clinical signs:
- other: No changes were noted in the general condition of any treated animals
- Gross pathology:
- No macroscopic abnormalities were found in any organs of the rats examined
- Other findings:
- Food intake in females appeared to be reduced on the day after dosing, then returned to normal; food intake in males was unaffected by treatment. Locomotion activity was normal in all treated rats.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity limit test, the LD50 of magnesium potassium fluoride silicate (Mg2.7K0.7Si4O10F2) was determined to be > 5000 mg/kg bw.
- Executive summary:
The acute oral toxicity of magnesium potassium fluoride silicate (Mg2.7K0.7Si4O10F2) was investigated in a non-guideline limit test. Male and female rats received single gavage doses of 5000 mg/kg bw. There were no deaths, no changes to body weight gain during the 14-day observation period, and no macroscopic abnormalities in the organs observed at necropsy. The LD50 was concluded to be > 5000 mg/kg bw.
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