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EC number: 949-694-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There is no requirement to generate experimental toxicokinetic data under REACH. No toxicokinetic data are identified; however a theoretical assessment of the toxicokinetic properties of the substance is made, based on existing toxicity data, and taking into account the physico-chemical properties of the substance.
Key value for chemical safety assessment
- Absorption rate - oral (%):
- 5
- Absorption rate - dermal (%):
- 5
- Absorption rate - inhalation (%):
- 100
Additional information
The following information is taken into account for any hazard / risk assessment:
General Notes
Micromica is a synthetic mica, a silicate mineral. Compositional analysis shows that Micromica is predominantly silicon dioxide (SiO2) and magnesium oxide (MgO), with smaller proportions of potassium oxide (K2O) and fluoride (F).
Oral Absorption
Under standard conditions, Micromica is a white crystalline powder, essentially insoluble in water. On this basis, it would be expected that Micromica would be poorly absorbed after oral administration. This prediction is supported by acute oral toxicity data on micromica, which reported an oral LD50 >5000 mg/kg bw, and on synthetic mica, in which “no adverse clinical signs or physical findings” were reported, with a reported oral LD50 >9000 mg/kg bw. Repeated-dose oral toxicity studies on the chemically and structurally similar material (synthetic mica) also found a lack of effects, even at doses as high as 5000 mg/kg bw/day (for 90 days), indicating a lack of absorption. A health-precautionary value of 5% has been taken forward for chemical safety assessment.
Dermal Absorption
Considering the structure, composition and very low aqueous solubility, dermal absorption is not expected. No systemic toxicity data using dermal administration are available, but there is no indication from local irritation studies that Micromica can penetrate the skin. A health-precautionary value of 5% has been taken forward for chemical safety assessment.
Inhalation Absorption
The mean particle size (D50) of Micromica is 8.376 μm, with a D10 of 3.65 μm and a D90 of 16.49 μm. Particle sizes below 10 μm are generally considered inhalable (i.e. able to reach the thoracic and alveolar regions of the lungs), and thus have the potential to cause adverse health effects after inhalation exposure. An acute inhalation toxicity study on a related substance did not find any effects even at the limit concentration (LC50 > 5.1 mg/L), indicating that even if Micromica were to reach the thoracic and alveolar regions of the lungs, it would not be absorbed. Nevertheless, a highly health-precautionary value of 100% has been taken forward for chemical safety assessment.
Distribution, Metabolism and Excretion
As it is essentially insoluble, if a small portion of Micromica was systemically absorbed, it would not be expected to be widely distributed to the tissues. As a crystalline, inorganic material, normal enzymatic metabolism would not be expected to effect any biotransformation on Micromica. The most likely outcome is excretion through the bile and faeces, with the substance essentially unchanged.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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