Registration Dossier
Registration Dossier
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EC number: 216-835-0 | CAS number: 1678-91-7
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is highly insoluble in water
- other:
- Justification for type of information:
- According to REACH, Annex XI, section 2, testing may be omitted if it is technically not possible to conduct the study as a consequence of the properties of the substance, e.g. very volatile substances.
According to the Guidance document “OECD SERIES ON TESTING AND ASSESSMENT Number 23: GUIDANCE DOCUMENT ON AQUATIC TOXICITY TESTING OF DIFFICULT SUBSTANCES AND MIXTURES, ENV/JM/MONO(2000)6, 14/12/2000”, more than 50 % of the substance could be lost from the water phase in 3-4 hours if the Henry’s law constant of the substance is greater than 100 Pa∙ m3 /Mol.
Since the vapour pressure of ECH is 1.730 kPa, a Henry’s law constant of 4.9 ∙ 104 Pa∙ m3 /Mol was calculated.
Therefore it can be expected that during testing for hydrolysis a significant amount of ECH will be lost from the test vessel and no reliable study result will be achieved.
For substances with high H-values the water phase is not the compartment of concern. In these cases a hydrolysis study is not justified.
Reference
Description of key information
According to REACH, Annex XI, section 2, testing may be omitted if it is technically not possible to conduct the study as a consequence of the properties of the substance, e.g. very volatile substances.
According to the Guidance document “OECD SERIES ON TESTING AND ASSESSMENT Number 23: GUIDANCE DOCUMENT ON AQUATIC TOXICITY TESTING OF DIFFICULT SUBSTANCES AND MIXTURES, ENV/JM/MONO(2000)6, 14/12/2000”, more than 50 % of the substance could be lost from the water phase in 3-4 hours if the Henry’s law constant of the substance is greater than 100 Pa∙ m3/Mol.
Since the vapour pressure of ECH is 1.730 kPa, a Henry’s law constant of 4.9 ∙ 104Pa∙ m3/Mol was calculated.
Therefore it can be expected that during testing for hydrolysis a significant amount of ECH will be lost from the test vessel and no reliable study result will be achieved.
For substances with high H-values the water phase is not the compartment of concern. In these cases a hydrolysis study is not justified.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
