Registration Dossier
Registration Dossier
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EC number: 219-834-3 | CAS number: 2549-51-1
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- other: expert assessment
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The assessment was based on the ready biodegradability of the hydrolysis products of VCA.
- Justification for type of information:
- The assessment was based on the ready biodegradability of the hydrolysis products of VCA.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The assessment was based on the ready biodegradability of the hydrolysis products of VCA.
- GLP compliance:
- no
- Inoculum or test system:
- not specified
- Remarks on result:
- other: see 'any other information on results incl. tables'
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The registered susbtance degrades upon contact with water and forms hydrolysis products which are further readily biodegradeable, therefore the registered substance can be considered as readily biodegradable.
- Executive summary:
VCA has been found to hydrolyse rapidly (t1/2 < 12 hrs) upon contact with water, to form two main degradation products: Chloroacetic acid (CAS 79-11-8 / EC 201-178-4) and Acetaldehyde (CAS 75-07-0 / EC 200-836-8). It is therefore not scientifically feasible to determine the ready biodegradability of VCA due to the fact it will degrade rapidly in water. In accordance with ECHA’s Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7b, it is advisable to give due consideration to the properties of the degradation products of a rapidly hydrolysable substance. Subsequently, expert judgement has been applied and the ready biodegradability of VCA will be determined from the existing biodegradability data for its degradation products.
Chloroacetic acid and Acetaldehyde are both considered to be readily biodegradable in the aquatic environment. Therefore, since it is known that the registered substance degrades upon contact with water and forms substances which are further readily biodegradable, VCA is to be considered as readily biodegradable for the purpose of endpoint fulfilment. No further testing for this endpoint is required.
Reference
It is not scientifically feasible to determine the biodegradability of VCA, due to the fact that it hydrolyses rapidly in water to form degradation products, Chloroacetic acid and Acetaldehyde. In accordance with ECHA’s Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7b, it is advisable to give due consideration to the properties of the degradation products of a rapidly hydrolysable substance.
Chloroacetic acid and Acetaldehyde are both considered to be readily biodegradable in the aquatic environment. Therefore, since it is known that the registered substance degrades upon contact with water and forms substances which are further readily biodegradable, VCA is to be considered as readily biodegradable for the purpose of endpoint fulfilment. No further testing for this endpoint is required.
Description of key information
VCA has been found to hydrolyse rapidly (t1/2 < 12 hrs) upon contact with water, to form two main degradation products: Chloroacetic acid (CAS 79-11-8 / EC 201-178-4) and Acetaldehyde (CAS 75-07-0 / EC 200-836-8). It is therefore not scientifically feasible to determine the ready biodegradability of VCA due to the fact it will degrade rapidly in water. In accordance with ECHA’s Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7b, it is advisable to give due consideration to the properties of the degradation products of a rapidly hydrolysable substance. Subsequently, expert judgement has been applied and the ready biodegradability of VCA will be determined from the existing biodegradability data for its degradation products.
Chloroacetic acid and Acetaldehyde are both considered to be readily biodegradable in the aquatic environment. Therefore, since it is known that the registered substance degrades upon contact with water and forms substances which are further readily biodegradable, VCA is to be considered as readily biodegradable for the purpose of endpoint fulfilment. No further testing for this endpoint is required.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
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