Vinyl chloroacetate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is hydrolytically unstable at pH 4, 7 and 9 (half-life less than 12 hours)

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
A hydrolysis study was performed on vinyl chloroacetate (VCA), in accordance with the OECD Guideline 111. A preliminary study was performed at pH 7 and 8. This preliminary study concluded that the hydrolysis was rapid: VCA completely hydrolysed in 24 hours at pH 7 and in 4 hours at pH 8. Due to the hydrolysis at pH 8 occurring much faster than expected, it was decided to perform the main study at pH 4 and 7 instead of pH 7 and 8. The main study reported half-lives of 1.22 hours at pH 7 and 3.92 hours at pH 4.
A trend was observed in the preliminary and main studies indicating that the half-life decreases when the pH increases. Therefore the half-life at pH 9 can be expected to be below 1.22 hours. Since the substance is hydrotically unstable at pH 4, 7, and 9 with half-lives below 12 hours, the water solubility study does not need to be conducted in accordance with Annex VII, Column 2, of REACH.

Description of key information

A hydrolysis study was performed on vinyl chloroacetate, in accordance with the OECD Guideline 111, and reported half-lives of 1.22 hours and 3.92 hours at pH 7 and pH 4, respectively. A trend was observed indicating that the half-life decreases when the pH increases therefore the half-life at pH 9 can be expected to be below 1.22 hours. Since the substance is hydrotically unstable at pH 4, 7, and 9 the water solubility study does not need to be conducted in accordance with Annex VII, Column 2, of REACH.