Registration Dossier
Registration Dossier
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EC number: 253-087-4 | CAS number: 36528-28-6
Endpoint summary
Administrative data
Description of key information
The substance is expected to have a low potential for bioaccumulation.
Additional information
The target substance decyl laurate (CAS 36528-28-6) is a long-chain aliphatic ester with a high estimated log Kow, which suggests a potential for bioaccumulation. However, since the substance has low water solubility and is readily biodegradable, no chronic exposure and relevant uptake by aquatic organisms is likely. Moreover, the biochemical processes involved in the metabolization of aliphatic esters, comprising enzymatic hydrolysis and the subsequent metabolization of the corresponding carboxylic acid and alcohol, are ubiquitous in the animal kingdom. Thus, in the unlikely event of uptake by fish, the substance is expected to be rapidly metabolized via enzymatic hydrolysis into its corresponding fatty acids and fatty alcohols. It is well known from literature that the resulting hydrolysis products will also be effectively metabolized and excreted by fish (Heymann, 1980; Lech & Bend, 1980; Lech & Melancon, 1980; Murphy & Lutenske, 1990; Sand et al., 1973).
In conclusion, the substance is expected to have a low potential for bioaccumulation.
REFERENCES
Heymann, E. (1980): Carboxylesterases and amidases. In: Jakoby, W.B., Bend, J.R. & Caldwell, J., eds., Enzymatic Basis of Detoxication, 2nd Ed., New York: Academic Press, pp. 291-323.
Lech, J., Melancon, M. (1980): Uptake, metabolism, and deposition of xenobiotic chemicals in fish. EPA-600 3-80-082. U.S. Environmental Protection Agency, Duluth, MN, USA.
Lech, J.J. & Bend, J.R. (1980): Relationship between biotransformation and the toxicity and fate of xenobiotic chemicals in fish. Environ. Health Perspec. 34, 115-131.
Murphy, P.G., Lutenske, N.E. (1990): Bioconcentration of haloxyfop-methyl in bluegill (Lepomis macrochirus Rafinesque). Environ. Intern. 16, 219-230.
Sand, D.M., Rahn, C.H., Schlenk, H. (1973): Wax esters in fish: Absorption and metabolism of oleyl alcohol in the gourami (Trichogaster cosby). J Nutr 103: 600-607.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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