Decyl laurate

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please refer to the analogue approach justification provided in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Duration:

21 d

Dose descriptor:

NOELR

Effect conc.:

>= 10 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

(WAF)

Basis for effect:

reproduction

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 95912-86-0, BASF, 2013, D. magna, 21 d

Duration:

21 d

Dose descriptor:

LOELR

Effect conc.:

> 10 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

(WAF)

Basis for effect:

reproduction

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 95912-86-0, BASF, 2013, D. magna, 21 d

Conclusions:

The retained effect value for long-term toxicity of the target substance to aquatic invertebrates is a NOELR (21 d) of ≥ 10.0 mg/L (nominal), based on the results of a GLP-guideline study with a closely related source substance (OECD 211, CAS 95912-86-0); read-across

Description of key information

No effects up to the limit of water solubility (OECD 211, D. magna); read-across

Additional information

There is no study available, in which the long-term toxicity of the target substance decyl laurate (CAS 36528-28-6) to aquatic invertebrates was assessed. Therefore, read-across to the structurally related source substance fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) was conducted in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substance is characterized by similar fatty acid chain lengths (C8-10) as well as alcohol components (C12-18-alkyl) and is therefore considered a suitable representative for the assessment of the long-term toxicity of the target substance to aquatic invertebrates. A detailed read-across justification is provided in the analogue justification in IUCLID Section 13.

The available study with the source substance Fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) was conducted according to OECD 211 and GLP. In a semi-static limit test, Daphnia magna was exposed to a nominal loading level of 10 mg/L test item for 21 d. Since the test item is a liquid with poor water solubility, the test solution was prepared as water accommodated fraction (WAF). Each individual test replicate was prepared separately in a liquid-liquid saturator exposure system comprised of a glass beaker containing a suspended, glass organism chamber with a stainless steel mesh bottom. The organism chamber prevented the test organisms from any direct contact with the undissolved test substance, while allowing full exposure to all soluble components in the WAF. The test item concentration in the test solution was not analytically verified due to technical limitations related to the low water solubility of the test substance (< 0.05 mg/L) for which no reliable analytical method could be developed. After 21 d, no significant mortality or any other significant adverse effects or abnormal behavior were observed in any of the test treatments. The data were not sufficient to calculate ECx values for reproduction or mortality. However, based on best professional judgment, a 21-day NOEC (21 d) ≥ 10 mg/L was estimated based on reproduction.

Based on the structural and chemical similarity of the target and source substance, the target substance is expected to exhibit a similar ecotoxicological profile as the source substance. Therefore, it can be concluded that decyl laurate (CAS 36528-28-6) does not cause long-term effects to aquatic invertebrates up to the limit of water solubility.