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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Aug 09- 26, 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
column elution method
Key result
Water solubility:
< 0.528 µg/L
Temp.:
20 °C
pH:
6.3

After substraction of the blank value:

Flow rate [mL/h]

Fraction No.

Volume of combined fractions [mL]

IS [µg/L]

Solubility of test item [µg/L]

 

 

 

 

12.5

1 (1-2)

20

101.5

0.18*

 

2 (3-4)

20

 101.5

 0.16*

 

3 (5-6)

20

 101.5

 0.17*

 

4 (7-8)

20

  101.5

 0.14*

 

5 (9-10)

20

  101.5

 0.14*

 

6 (11-12)

20

  101.5

 0.18*

 

7 (13-14)

20

  101.5

 0.15*

 

8 (15-16)

20

  101.5

 0.16*

 

 

 

 

 

 

6.25

1 (1-2)

20

  101.5

n.d.

 

2 (3-4)

20

 101.5

n.d

 

3 (5-6)

20

  101.5

n.d.

 

4 (7-8)

20

  101.5

n.d.

 

5 (9-10)

20

  101.5

n.d.

 

6 (11-12)

20

 101.5

0.10*

 

7 (13-14)

20

  101.5

11.66

 

8 (15-16)

20

  101.5

0.15*

* below the lowest calibration level (0.528 µg/L)

The water solubility at flow rates of 6.25 mL/h and 12.5 mL/h yielded values below the lowest calibration level (< 0.528 µg/L) at the concentration plateau of five successive fractions. As an exception fraction 7 at a flow rate of 6.25 mL/h yielded 11.66 µg/L.

The WS was determined at 20 °C. The pH value of the collected aqueous fractions was 6.3.

Description of key information

< 0.528 µg/L at 20 °C and pH = 6.3 (OECD 105)

Key value for chemical safety assessment

Additional information