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EC number: 947-476-4
CAS number: -
pre-natal developmental toxicity study was conducted to assess the
developmental or teratogenic potential of
N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine in Himalayan
rabbits according to the OECD Guideline 414 and in compliance with GLP.
of 20 pregnant females received the substance by gavage at dose levels
of 0, 6, 9 and 20 mg a.i./kg bw/day during Days 6 -28 of gestation.
Animals were sacrificed on gestation Day 29.
toxicity was indicated at 20 mg a.i./kg bw/day by the death of two dams
and by marginally reduced body weight and food intake during the last
days of pregnancy. Necropsy revealed an irritation of the
gastrointestinal tract in 5 dams and an increased incidence of
resorptions. Marginal increased incidence of resorptions suggesting
early embryonic deaths secondary to maternal toxicity was observed at 20
mg a.i./kg bw/day. No substance-related influence was detected on the
pre-natal foetal development. The incidences of foetal malformations,
variations and retardations were similar in all groups. As a result, the NOAELs
for both maternal and embryotoxicity were set at 9 mg a.i./kg bw/day and
the NOAEL for teratogenicity was set at 20 mg a.i./kg bw/day.
the conditions of the study, the test substance was not considered to be
a developmental toxicant.
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