Anisoyl chloride

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Fragrance material review on p-anisyl acetate

Author:

D. McGinty, C.S. Letizia, A.M. Api

Year:

2012

Bibliographic source:

Food and Chemical Toxicology, 50, (2012), S502–S506

Reference 2

Reference Type:

publication

Title:

Fundamental Studies of Safe Compound Perfumes for Cosmetics Part 1 The Primary Irritation of Compound Materials to the Skin

Author:

Toshio Takenaka, Eiko Hasegawa, Umeko Takenaka, Fumio Saito M. D. and Tazuko Odaka M. D

Year:

1968

Bibliographic source:

Journal of J.C.C.A. Special Issue (1968) Pg 313–329

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

A patch test of test chemical p-anisyl acetate (CAS No: 104-21-2) was conducted on 80 patients to assess its skin irritation potential.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

p-methoxybenzyl acetate

EC Number:

203-185-8

EC Name:

p-methoxybenzyl acetate

Cas Number:

104-21-2

Molecular formula:

C10H12O3

IUPAC Name:

4-methoxybenzyl acetate

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report): Anisyl acetate
- Molecular formula (if other than submission substance): C10-H12-O3
- Molecular weight (if other than submission substance): 180.202
- Substance type: Organic
- Physical state: No data available
- Purity 97%
- Impurities (identity and concentrations): No data available

Specific details on test material used for the study:

- Name of test material (as cited in study report): p- Anisyl acetate
- Molecular formula : C10-H12-O3
- Molecular weight: 180.202
- Substance type: Organic
- Physical state: liquid
- Smiles: c1(ccc(OC)cc1)COC(C)=O
- InChI: 1S/C10H12O3/c1-8(11)13-7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3

Test animals

Species:

human

Strain:

other: not applicable

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Tokyo, Osaka
- Age at study initiation:16-45 yrs of age
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available


ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

IN-LIFE DATES: From: To: September 1963- December 1967

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

other: Cream base or 99% ethyl alcohol

Controls:

yes, concurrent vehicle

Amount / concentration applied:

0.05-0.5 %

Duration of treatment / exposure:

24-48 hrs

Observation period:

30 mins after patch removal

Number of animals:

80 humans

Details on study design:

TEST SITE
- Area of exposure: back, forearm (flexor) and upperarm (inside flexion side)
- % coverage: No data available
- Type of wrap if used: No data available

REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data available
- Time after start of exposure: No data available

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 30 min after patch removal

Score:

0

Reversibility:

no data

Remarks on result:

other: No irritation was observed

Irritant / corrosive response data:

No irritation was noted in any of the treated human.

Applicant's summary and conclusion

Interpretation of results:

other: not irritating

Conclusions:

The test material anisyl acetate (CAS No: 104-21-2) when applied as a patch did not show any reaction. This suggests Anisyl acetate to be non irritant to the skin.

Executive summary:

A patch test of test chemical p-anisyl acetate (CAS No: 104-21-2) was conducted on 80 patients to assess its skin irritation potential

 

Anisyl acetate was applied as a closed patch to the back, forearm and upperarm of 80 male/female humans in Japan. The test material was applied at a concentration of 0.05-0.5%. Cream base or ethyl alcohol was used as a vehicle.

 

The patches were applied for 24–48 h and the sites evaluated 30 min after the patches were removed.

 

No irritation was noted in any of the human (0/80). ThereforeAnisyl acetate(CAS No: 104-21-2) was considered to be non-irritant to the skin.