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EC number: 202-816-4
CAS number: 100-07-2
In the combined repeated dose toxicity
study with the reproduction/developmental toxicity screening test (OECD
TG 422), male and female rats were treated with p-methoxybenzaldehyde in
the concentration of 0, 20, 100 and 500 mg/kg bw orally by gavage for
approx. 63 days. Epididymidal weight was decreased in males at 500 mg/kg
group. The compound showed no adverse effects in terms of estrous cycle,
number of corpora lutea and implant rate at any dose level. In the 500
mg/kg bw group, the number of non-pregnant females was increased
although all pairs copulated. The delivery index was lower than in
controls at 500 mg/kg bw/day. In addition, the number of pups and the
number of live pups on lactation day 0 and 4 were lower than in the
controls at 500 mg/kg bw/day. No effect on viability of treated rats was
observed as compared to control. No effect on body weight of pups
observed as compared to control. Therefore, NOAEL was considered to be
100 mg/kg bw for P and F1 generation when male and female rats were
treated with p-methoxybenzaldehyde orally by gavage for approx. 63 days.
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