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EC number: 212-112-9 | CAS number: 763-69-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A 28-study in rats with oral gavage administration of the test material is available for ethyl 3-ethoxypropionate. This study was conducted under GLP and according to OECD guideline 407. For the inhalation route a 90-day in rats conducted under GLP and according to OECD guideline 413 and a non-GLP two-week inhalation study in rats equivalent to OECD guideline 412 are available. In addition a repeated exposure dermal irritation study (non-GLP, not following any guideline) in guinea pigs is available.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 500 mg/m³
Additional information
Oral: In a 28-day study in rats with oral gavage administration of the test material no significant adverse effects were observed with ethyl 3-ethoxypropionate. At the highest dose level (1000 mg/kg bw/day) the aspartate aminotransferase and creatinine levels were slightly increased in both sexes, the sorbitol dehydrogenase levels were moderately increased in the males and slightly increased in the females, and the alanine aminotransferase levels were slightly increased in the females. The probable site of toxic action is the liver. The clinical chemistry determinations of the lower dose (100 mg/kg bw/day) males were comparable to the controls. The no observed adverse effect level (NOAEL) for Ethyl 3-Ethoxypropionate is 1000 mg/kg bw/day based on slight changes in liver enzymes. The no observed effect level (NOEL) is 100 mg/kg bw/day.
Inhalation: in a 90-day vapor inhalation study with rats the most notable systemic effect of EEP exposure was a decrease in body weight gain for males and females exposed to 1000 or 500 ppm. The cause of the decreased weight gain was not determined. There were no statistically significant clinical pathologic findings or organ weight changes that were indicative of a toxic response, or any histopathologic findings to suggest a pathologic effect. It is concluded that the principal systemic effect following exposure to 1000 and 500 ppm EEP is a statistically significant decreased body weight gain. Although EEP was not without toxicity the effects seen were of a non-specific nature and did not permit the identification of a target tissue. The no-observed effect level for systemic toxicity is 250 ppm EEP and the no-observed adverse effect level for systemic effects is 500 ppm. This data is supported by a two-week inhalation study in rats with no adverse systemic effects observed up to the limit dose of 1000 ppm.
In addition to those systemic effects slight local irritation was observed at 250 ppm. Therefore, this dose level is considered to be the LOAEC for local effects.
Dermal: repeated applications (9 over a 10 day period) to the clipped backs of guinea pigs produced slight exacerbation of the irritative response. No evidence of percutaneous absorption was seen.
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver
Justification for classification or non-classification
The no observed adverse effect levels for ethyl 3 -ethoxypropionate exceed the values triggering classification via all routes of exposure. Therefore no classification for prolonged exposure is required.
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