Benzene-1,4-diammonium sulphate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23-03-2017 – 28-03-2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Principles of method if other than guideline:

The water solubility determination of test item Benzene-1,4-diammonium sulphate (CAS No. 16245-77-5) was done as per the OECD guideline 105 and by spectrophotometric analytical method as per OECD 101.

GLP compliance:

not specified

Type of method:

other: Sectrophotometric analytical method

Specific details on test material used for the study:

- Name of test material : Benzene-1,4-diammonium sulphate- IUPAC name: Benzene-1,4-diammonium sulphate- Molecular formula: C6 H8 N2.H2 O4 S- Molecular weight: 206.221 g/mol- Smiles notation: S(=O)(=O)(O)O.c1(ccc(cc1)N)N - InChl : 1S/C6H8N2.H2O4S/c7-5-1-2-6(8)4-3-5;1-5(2,3)4/h1-4H,7-8H2;(H2,1,2,3,4)- Substance type: organic- Physical state: Solid powder (off white)- Purity: NM

Key result

Water solubility:

3 705.655 mg/L

Conc. based on:

test mat.

Temp.:

30 °C

Remarks on result:

other: no other details mentioned

WATER SOLUBILITY: PRELIMINARY TEST

0.1g of test item was taken in 100 ml beaker. RO water was added in increasing amount in sequence of 0.1 ml, 0.5 ml, 1.0 ml, 2.0 ml, 10.0 ml and 100.0 ml with intermediate stirring.

For soluble substances: Preliminary water solubility of test item was found 0.1g in >100 ml RO water. For analytical determination 0.1 g of test item was dissolved in 100 ml of RO water. The solution was kept for 24hrs on stirring and absorbance was recorded. Concentration detected on the basis of standard curve was 981.4925 mg/L. Five times the concentration recorded from preliminary solubility was used for confirmatory study.

WATER SOLUBILITY: CONFIRMATORY TEST

Five times the concentration recorded from preliminary solubility = 981.4925 mg/L × 5 = 4907.4625 mg/L was used for confirmatory study. Two separate solution of 490.74625 mg in 100 ml RO water were prepared and kept for stirring for hrs, 48 hrs and 72 hrs. After the completion of stirring period the absorbance for all the two solution were recorded and concentration was detected on the basis of standard curve. Table 2 refers to the same.

Sample Stirring time (hours)	Concentration obtained on the basis of standard curve (mg/l)	Dilution factor	Solubility value obtained (mg/l)
24	-	-	-
48	8.7459	400	3498.36
72	7.8259	500	3912.95

Considering the water solubility for 48 hrs and 72 hrs the mean water solubility was calculated as follows:

Mean water solubility value for 48 hour run sample + 72 hour run sample

=(3498.36+3912.95)/2

=3705.655 mg/L

Conclusions:

The water solubility for the test item Benzene-1,4-diammonium sulphate was found to be 3705.655 mg/L at 30°C.

Executive summary:

The water solubility determination of test item Benzene-1,4-diammonium sulphate (CAS No. 16245-77-5) was done as per the OECD guideline 105 and by spectrophotometric analytical method as per OECD 101. The solubility of Benzene-1,4-diammonium sulphate (CAS: 16245-77-5) in water was determined to be 3705.655 mg/L at 30°C.

Hence on the basis of experimental value the given chemical is considered to be soluble in water.

Description of key information

The water solubility for the test item Benzene-1,4-diammonium sulphate was found to be 3705.655 mg/L at 30°C.

Key value for chemical safety assessment

Water solubility:

3 705.655 mg/L

at the temperature of:

30 °C

Additional information

The water solubility determination of test itemBenzene-1,4-diammonium sulphate (CAS No. 16245-77-5) was done as per the OECD guideline 105 and by spectrophotometric analytical method as per OECD 101. The solubility of Benzene-1,4-diammonium sulphate (CAS: 16245-77-5) in water was determined to be 3705.655 mg/L at 30°C. Hence on the basis of experimental value the given chemical is considered to be soluble in water.