Registration Dossier
Registration Dossier
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EC number: 272-812-5 | CAS number: 68915-39-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexane, oxidized, aq. ext., sodium salt
- EC Number:
- 272-812-5
- EC Name:
- Cyclohexane, oxidized, aq. ext., sodium salt
- Cas Number:
- 68915-39-9
- Molecular formula:
- Unspecified (UVCB substance)
- IUPAC Name:
- Cyclohexane, oxidized, aq. ext., sodium salt
- Details on test material:
- - Name of test material (as cited in study report): Anolonablauge
- Composition of test material, percentage of components:
Adipic acid (Cas No. 124-04-9) 4.8%
Hexanoic acid, 6-hydroxy (Cas No. 1191-25-9) 4.1%
Glutaric acid (Cas No. 110-94-1) 0.7%
Succinic acid (Cas No. 110-15-6) 0.5%
Valeric acid (Cas No. 109-52-4) 4.8%
Hexaconic acid (Cas No. 142-62-1) 1.2%
Butyric acid (Cas No. 107-92-6) 1.0%
Propionic acid (Cas No. 79-09-4) 0.3%
Acetic acid (Cas No. 64-19-7) 0.5%
Formic acid (Cas No. 64-18-6) 1.5%
Sodium 9.0%
Sodium carbonate (Cas No. 497-19-8) 0.5%
Sodium hydrogencarbonate (Cas No. 144-55-8) 1.0%
Water (Cas No. 7732-18-5) 55.0 %
Cobalt 4 ppm
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach
- Mean weight at study initiation: male 3.01 Kg, female 2.76 Kg
- Housing: one per cage
- Diet: Kliba 341, about 130 g/animal/day
- Water: 250 ml tap water/animals/day
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipping
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin sites of the same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 72 h
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lutrol and lutrol/water (1:1)
- Time after start of exposure: 4 h
SCORING SYSTEM: Draize scoring. Readings were taken 30-60min after removal of the test patches and 24h, 48h, 72h after the beginning of the application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
