Registration Dossier
Registration Dossier
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EC number: 272-812-5 | CAS number: 68915-39-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Cyclohexane, oxidized, aq. ext., sodium salt
- EC Number:
- 272-812-5
- EC Name:
- Cyclohexane, oxidized, aq. ext., sodium salt
- Cas Number:
- 68915-39-9
- Molecular formula:
- Unspecified (UVCB substance)
- IUPAC Name:
- Cyclohexane, oxidized, aq. ext., sodium salt
- Details on test material:
- - Name of test material (as cited in study report): Anolonablauge
- Composition of test material, percentage of components:
Adipic acid (Cas No. 124-04-9) 4.8%
Hexanoic acid, 6-hydroxy (Cas No. 1191-25-9) 4.1%
Glutaric acid (Cas No. 110-94-1) 0.7%
Succinic acid (Cas No. 110-15-6) 0.5%
Valeric acid (Cas No. 109-52-4) 4.8%
Hexaconic acid (Cas No. 142-62-1) 1.2%
Butyric acid (Cas No. 107-92-6) 1.0%
Propionic acid (Cas No. 79-09-4) 0.3%
Acetic acid (Cas No. 64-19-7) 0.5%
Formic acid (Cas No. 64-18-6) 1.5%
Sodium 9.0%
Sodium carbonate (Cas No. 497-19-8) 0.5%
Sodium hydrogencarbonate (Cas No. 144-55-8) 1.0%
Water (Cas No. 7732-18-5) 55.0 %
Cobalt 4 ppm
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean weight at study initiation: male 181 g, female 180 g
- Fasting period before study: 16 h before administration
- Housing: 5 per cage
- Diet (e.g. ad libitum): Kliba-Labordiet 343
- Water (e.g. ad libitum): tap water
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle (g/100 ml): 20
- Amount of vehicle (if gavage): 10 ml/kg bw
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: body weight at the begining, day 7 and 13 of the study. Recording of signs and symptoms several times on the day of administration, at least once each workday, check for moribund and dead animals twice each workday and once on holidays.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortalities were observed.
- Clinical signs:
- No clinical signs were observed.
- Body weight:
- The animals gained body weight during 14 days study period.
- Gross pathology:
- no abnormalities were observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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