Registration Dossier
Registration Dossier
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EC number: 211-617-1 | CAS number: 674-82-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1967
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract only
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 967
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not specified
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Remarks:
- performed before GLP guidelines
Test material
- Reference substance name:
- But-3-en-3-olide
- EC Number:
- 211-617-1
- EC Name:
- But-3-en-3-olide
- Cas Number:
- 674-82-8
- Molecular formula:
- C4H4O2
- IUPAC Name:
- 4-methylideneoxetan-2-one
- Reference substance name:
- Diketene
- IUPAC Name:
- Diketene
- Details on test material:
- no data
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 20
- Max. score:
- 20
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 5
- Max. score:
- 10
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-48 hours
- Score:
- 70
- Max. score:
- 80
- Reversibility:
- not fully reversible within: 72 hours
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 60
- Max. score:
- 80
- Reversibility:
- not fully reversible within: 72 hours
- Irritant / corrosive response data:
- no data
- Other effects:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based on the scores obtained from the eye irritation study in rabbits and the irreversibility within 72 hours Diketene is considered to be irritating to the eye.
- Executive summary:
Please refer to "Conclusions".
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