Registration Dossier
Registration Dossier
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EC number: 211-617-1 | CAS number: 674-82-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1967
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract only
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 967
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: H.F. Smyth et al., 1962, Range finding toxicity data: List VI, Am. Ind. Hyg. J., 23, 95-107
- Deviations:
- not specified
- Principles of method if other than guideline:
- Material tested by the prescribed techniques of the FHSLA (Federal Hazardous Substances Labeling Act) applying the Draize scale for scoring.
- GLP compliance:
- no
- Remarks:
- performed before GLP guidelines
Test material
- Reference substance name:
- But-3-en-3-olide
- EC Number:
- 211-617-1
- EC Name:
- But-3-en-3-olide
- Cas Number:
- 674-82-8
- Molecular formula:
- C4H4O2
- IUPAC Name:
- 4-methylideneoxetan-2-one
- Reference substance name:
- Diketene
- IUPAC Name:
- Diketene
- Details on test material:
- no data
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- open
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 mL
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 24 h
- Number of animals:
- 5 per dose
- Details on study design:
- Method:
Primary skin irritation on rabbits is recorded in a 10 -grade ordinal series an is based upon the severest reaction that develops on the clipped skin of each of 5 albino rabbits within 24 hours of the uncovered application of 0.01 ml of undiluted sample.
Evaluation system:
Grade 1 in indicates no irritation and Grade 2 the least visible capillary infection from the undiluted chemical. Grade 6 indicates necrosis ehen undiluted and Grade 10 indicates necrosis from a 0.01 % solution
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Draize units
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 4.9
- Max. score:
- 10
- Reversibility:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: refer to "Details on study design"
- Conclusions:
- Based on the results of this skin irritation study in rabbits Diketene might be considered as moderately irritant.
- Executive summary:
Please refer to "Conclusions".
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