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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

EC50 3h (freshwater OECD 209 study on activated sludge): >1000 mg/L
NOEC 3h (freshwater OECD 209 study on activated sludge): >1000 mg/L

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L
EC10 or NOEC for microorganisms:
1 000 mg/L

Additional information

One experiment was performed.

All validity criteria were met. For the estimation of the EC50 of the positive control, the fits showed good statistical correspondence of the data with the dose-response-equation. The positive control gave an EC50 of 11 mg/L which lie within the recommended range of 2 – 25 mg/L. The coefficient of variation of oxygen uptake rate in control replicates was below 30 % at the end of the test. The oxygen uptake rate of the blank controls was above 20 mg O2per gram activated sludge in 1 hour.

The test item was tested using 5 concentrations ranging from 1000 to 1 mg/L nominal concentration. For the highest test item concentration 1000 mg/L, 5 replicates were tested. Because no inhibition was observed at the highest test concentration, the NOEC was determined as 1000 mg/L and the EC50 as > 1000 mg/L. No observations were made which might cause doubts concerning the validity of the study outcome.


The result of the test can be considered valid.