Registration Dossier
Registration Dossier
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EC number: 915-334-0 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC10 (3 h) of > 1000 mg/L
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of Reaction mass of
octadecyl heptanoate and octadecyl octanoate (List No. 915-334-0) to
activated sludge microorganisms are available, in accordance to
Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the
structurally related source substance Fatty acids, C8-10, C12-18-alkyl
esters (CAS 95912-86-0) was conducted. The read-across substance is
representative to evaluate the toxicity of the target substance to
activated sludge microorganisms.
The
target substance is a multi-constituent substance specified by mainly C7
and C8 linear fatty acids esterified with a linear alcohol of a chain
length of C18. The source substance Fatty acids, C8-10, C12-18-alkyl
esters (CAS 95912-86-0) is an UVCB substance predominantly consisting of
esters with a C8-C10 fatty acid and a C12-C14 alcohol moiety. A detailed
analogue approach justification is provided in the technical dossier
(see IUCLID Section 13). The source substance has a similar structure
and is suitable for read across to the target substance. In this case of
read-across, the best suited (highest degree of structural similarity,
nearest physico-chemical properties) read-across substance was used for
the assessment.
The study with the source substance fatty acids, C8-10, C12-18-alkyl
esters (CAS 95912-86-0) was performed according to OECD 209 (GLP)
investigating the toxicity to microorganisms (Hammer, 2013). Activated
sludge microorganisms (from a municipal wastewater treatment plant) were
exposed to the test substance up to a nominal concentration of 1000
mg/L. No effects were observed based on the respiration rate after 3 h
of incubation resulting in an EC10 (3 h) of > 1000 mg/L. An increase of
respiration was recorded in all treatments compared to the control
values.
Based on the available result from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a comparable structure, it can be concluded that Reaction mass of octadecyl heptanoate and octadecyl octanoate will not exhibit effects on activated sludge microorganisms.
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