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EC number: 915-334-0 | CAS number: -
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 75.3% based on BOD after 28 d (OECD 301C)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Since no studies investigating the ready biodegradability of
Reaction mass of octadecyl heptanoate and octadecyl octanoate (List No.
915-334-0) are available, in accordance to Regulation (EC) No 1907/2006
Annex XI, 1.5 a read-across to the structurally related source substance
docosyl docosanoate (CAS 17671-27-1) was conducted. The read-across
substance is representative to evaluate the biodegradation of Reaction
mass of octadecyl heptanoate and octadecyl octanoate (target substance).
The target substance is a multi-constituent substance specified by
mainly C7 and C8 linear fatty acids esterified with a linear alcohol of
a chain length of C18. The source substance Docosyl docosanoate is an
UVCB substance of a linear C22 fatty acid and a linear C22 alcohol. The
potential for ready biodegradation is dependent on the chain lengths of
the fatty acid and the alcohol. Therefore, a substance with longer
chains of fatty acid and alcohol is considered reliable to assess the
biodegradation of the target substance.In this case of read-across, the
best suited (highest degree of structural similarity, nearest
physico-chemical properties) read-across substance was used for the
assessment.This read-across is justified in detail in the overall
summary (IUCLID Section 6.1) and within the analogue justification in
IUCLID Section 13.
Moreover, the biodegradation of two representative constituents of the
target substance was assessed using the VEGA v1.0.8 (Q)SAR model.
The study with the source substance Docosyl docosanoate
(CAS 17671-27-1) was performed according to OECD 301C (GLP) under
aerobic conditions using a mixture of activated sludge from STP with
freshwater from rivers and lakes, marine water and marine sediment as
inoculum with a test substance concentration of 100 mg/L (Ministry of
Economy, Trade and Industry, Japan, 1992). A biodegradation of 75.3%
(BOD) was observed after 28 d. Since the substance reached the pass
level for OECD 301C (biodegradation is > 60% after 28 d, no 10-day
window required) Docosyl docosanoate is readily biodegradable according
to the OECD criteria.
Supporting
(Q)SAR predictions using VEGA v1.0.8 showed that the main components of
the target substance are readily biodegradable. The prediction is valid
and reliable. Similar molecules with experimental data were found within
the training set showing that the substance is readily biodegradable.
This result strongly supports the experimental study with a structurally
very similar source substance as discussed above.
Based
on the results from one structurally related read-across substance (in
accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) in combination
with reliable (Q)SAR data for the target substance, it can be concluded
that the target substance Reaction mass of octadecyl heptanoate and
octadecyl octanoate (List No. 915-334-0) is readily biodegradable
according to the OECD criteria.
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