Registration Dossier
Registration Dossier
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EC number: 915-334-0 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of Reaction mass of
octadecyl heptanoate and octadecyl octanoate (List No. 915-334-0) to
aquatic algae are available, in accordance to Regulation (EC) No
1907/2006 Annex XI, 1.5 a read-across to the structurally related source
substance Fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) was
conducted. The read-across substance is representative to evaluate the
toxicity of Reaction mass of octadecyl heptanoate and octadecyl
octanoate (target substance) to aquatic algae.
The target substance is a multi-constituent substance specified by
mainly C7 and C8 linear fatty acids esterified with a linear alcohol of
a chain length of C18. The source substance Fatty acids, C8-10,
C12-18-alkyl esters (CAS 95912-86-0) is an UVCB substance predominantly
consisting of esters with a C8-C10 fatty acid and a C12-C14 alcohol
moiety. A detailed analogue approach justification is provided in the
technical dossier (see IUCLID Section 13). The source substance has a
similar structure and is suitable for read across to the target
substance. In this case of read-across, the best suited (highest degree
of structural similarity, nearest physico-chemical properties)
read-across substance was used for the assessment.
This read-across is justified in detail in the overall summary (IUCLID
Section 6.1) and within the analogue justification in IUCLID Section 13.
The study with the source substance Fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) was conducted according to OECD 201 (GLP) investigating the toxicity to aquatic algae (Salinas, 2013). Desmodesmus subspicatus was exposed to nominal loading rates of 10, 32, 100, 320 and 1000 mg/L for 72 h (Water Accommodated Fraction). No effects were observed on growth and yield after 72 h of exposure resulting in an EL50 (72 h) > 1000 mg/L and a NOELR (72 h) ≥ 1000 mg/L.
Based on the results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a comparable structure, it can be concluded that Reaction mass of octadecyl heptanoate and octadecyl octanoate willnot exhibit effects to aquatic algae up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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