Methacrylic acid, monoester with propane-1,2-diol

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: human patch test data collection

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Remarks:

Bias-positive: patients of dermatologists or dermal clinics are a cohort preselected for having a problem with the skin, so that no valid assessment of actual prevalence can be done.

Data source

Reference

Reference Type:

publication

Title:

Allergic contact dermatitis to artificial fingernails prepared from UV light-cured acrylates

Author:

Hemmer W., Focke M., Wantke F., Götz M., Jarisch R.

Year:

1996

Bibliographic source:

Journal of the American Academy of Dermatology 35: 377 - 380

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

Methacrylic acid, monoester with propane-1,2-diol

EC Number:

248-666-3

EC Name:

Methacrylic acid, monoester with propane-1,2-diol

Cas Number:

27813-02-1

Molecular formula:

C7H12O3

IUPAC Name:

1-hydroxypropan-2-yl 2-methylprop-2-enoate; 2-hydroxypropyl 2-methylprop-2-enoate

Test material form:

liquid

Details on test material:

The chemical 2-propenoic acid, 2-methyl-, monoester with 1,2-propanediol (CAS No. 27813-02-1) consists of two isomers. This occurs due to the method of industrial production, which is usually either the reaction between methacrylic acid and propylene oxide, or methacrylic acid esterification of 1,2-propanediol. The predominant isomer is the secondary alcohol 2-propenoic acid, 2-methyl, 2-hydroxypropyl ester, which is assigned the CAS No. 923-26-2, and the isomer 2-propenoic acid, 2-methyl, 2-hydroxy- 1-methylethyl ester, the other chemical in this group, for which CAS 4664-49-7 is assigned. The purification of the two isomers requires extensive effort and it is supposed no such effort has been taken during data collection otherwise noted. Therefore toxicity information for both CAS No. 923-26-2 and CAS No. 27813-02-1 is considered to be applicable to both chemicals..

Results and discussion

Any other information on results incl. tables

Patients wearing photoboned acrylic nails who had
perionychial and subonychial eczema were patch tested with
an acrylate battery and "hypoallergenic" commercial
products. 5 out of 5 patients showed a positive patch test
reaction at a test concentration of 0.6 % 2-HPMA in
petrolatum. At a test concentration of 0.2 % 2-HPMA in
petrolatum all 5 patients were also positive but the
reaction was weak in 4 of them. At a test concentration of
0.02 % 2-HPMA in petrolatum only one out of the five
patients showed a positive reaction.