Registration Dossier
Registration Dossier
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EC number: 210-817-6 | CAS number: 623-84-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- circa 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Groups of 5 rats received 0.5, 1.0 or 2.0 ml/kg and were observed for 14 days.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Propane-1,2-diyl diacetate
- EC Number:
- 210-817-6
- EC Name:
- Propane-1,2-diyl diacetate
- Cas Number:
- 623-84-7
- Molecular formula:
- C7H12O4
- IUPAC Name:
- propane-1,2-diyl diacetate
- Details on test material:
- A liquid sample was obtained from the R&D group, South Charleston, West Virginia Lot 22_DS-60-2; RD-6884
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino rats were used. In other sections of report, Wistar rats were used
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.5, 1.0 or 2.0 ml/kg
- No. of animals per sex per dose:
- 5 male rats/dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1.41 mL/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Rats dosed with 2.0 ml/kg died on the day of dosing. Signs and/or symptoms were very sluggish behavior with rapid breathing.
Rasts dosed with 0.5 or 1.0 ml/kg survived the 14 day observation period. Rats gained weight during the observation period.
Applicant's summary and conclusion
- Conclusions:
- The ip LD50 in rats was 1.41 ml/kg.
- Executive summary:
The acute toxicity following ip administration was examined. The ip LD50 in rats was 1.41 ml/kg.
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