2-chloropyridine

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Study period:

1991

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study without detailed documentation.

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1991

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

not specified

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3-methylpyridine

EC Number:

203-636-9

EC Name:

3-methylpyridine

Cas Number:

108-99-6

IUPAC Name:

3-methylpyridine

Details on test material:

- Name of test material (as cited in study report): 3-Methylpyridine

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
- Melting point: -18.1ºC
- Boiling point: 143-144ºC
- Vapour pressure: 6.05 mm Hg at 25ºC
- Water solubility (under test conditions):
- Henry's law constant: 7.73 x 10E-6 atm-cu m/mol at 25ºC
- log Pow: 1.20
- pKa: 5.63 at 25ºC

Reference: HSDB® is provided quarterly by US National Library of Medicine and was last updated December 18, 2009

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

no

Details on test solutions:

Dilution water was reconstituted water prepared according to ISO-6341, 1982, with micronutrients.

Test solutions were prepared by adding an aliquot of a stock solution (1.0077 g 3-methylpyridine/l) to the dilution water.

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

- Common name: Daphnia magna
- Strain: Straus
- Source: State University of Ghent
- Age at study initiation (mean and range, SD): < 24 hours old

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test conditions

Hardness:

250 – 25 mg/L as CaCO3

Test temperature:

Not reported in summary.

pH:

7.7 ± 0.1

Dissolved oxygen:

oxygen-saturated

Nominal and measured concentrations:

Nominal concentrations: 0, 100, 180, 320, 560, and 1000 mg/L

Details on test conditions:

Test vessels were 80-mL all glass tubes containing 50 mL of test solution. Test solutions were prepared by adding an aliquot of a stock solution to the dilution water. Four replicate test tubes were used per concentration and each test tube held 5 daphnids.

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

320 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 2

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

180 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Reported statistics and error estimates:

No statistics applied to data.

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified