Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 205-736-8 | CAS number: 149-30-4
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: publication does not give sufficient experimental details
Data source
Reference
- Reference Type:
- publication
- Title:
- Testing of selected workplace chemicals for teratogenic potential
- Author:
- Hardin, B., D.; et al.
- Year:
- 1 981
- Bibliographic source:
- Scand j work environm. health 7, suppl. 4, 66-75
Materials and methods
- Principles of method if other than guideline:
- other: developmental toxicity study
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Details on test material:
- MBT
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- day 1 to day 15 of gestation
- Frequency of treatment:
- daily
- Duration of test:
- up to day 21 of gestation
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 200 mg/kg bw
Basis:
- Control animals:
- yes
Results and discussion
Any other information on results incl. tables
MBT administration: treatment-related effects were limited to evidence of maternal or fetal toxicity. No adverse effects on fetal development were indicated.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
