Registration Dossier
Registration Dossier
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EC number: 205-736-8 | CAS number: 149-30-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of mercaptobenzothiazole
- Author:
- Randall, D., J.; et al.
- Year:
- 1 990
- Bibliographic source:
- Journal of American College of Toxicology, part B, vol.1, 62
Materials and methods
- Principles of method if other than guideline:
- other: acute oral toxicity study
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity study
- Limit test:
- no
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Details on test material:
- mercaptobenzothiazole (MBT) THIOTAX powder, purity: 97.4 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 3160, 3980, 5010, 6310 mg/kg bw
- No. of animals per sex per dose:
- 5 (males and females mixed)
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 800 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 530 - 4 100
- Remarks on result:
- other: Clinical signs: reduced appetite and activity, increased weakness, collapse and death.
Any other information on results incl. tables
Mortality:
3160 mg/kg bw: 0/3 males, 0/2 females, combined: 0/5
3980 mg/kg bw: 0/2 males, 3/3 females, combined: 3/5
5010 mg/kg bw: 3/3 males, 2/2 females, combined: 5/5
6310 mg/kg bw: 2/2 males, 3/3 females, combined: 5/5
Time of mortality: one to three days
The calculated oral LD50 for MBT was 3800 mg/kg (95% confidence limits 3530 - 4100 mg/kg bw). For the doses of 3160, 3980, 5010 and 6310 mg/kg, the number of deaths were 0, 3, 5 and 5, respectivly, out of 5 animals per group. Clinical signs included reduced appetite and activity (1 to 3 days in survivors), increasing weakness, collapse and death. Autopsy of decedents showed lung hypermia, slight liver discoloration, and gastrointestinal inflammation. Viscera of surviving animals appeared normal at sacrifice.
Applicant's summary and conclusion
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