Registration Dossier
Registration Dossier
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EC number: 219-553-6 | CAS number: 2461-15-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- Meets National standards method with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- Four albino rats were exposed to a saturated atmosphere (nominal concentration: 0.15 mg/l) for 7 hours at room temperature.
- GLP compliance:
- no
- Remarks:
- pre-dates GLP guideline
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 68609-97-02
- IUPAC Name:
- 68609-97-02
- Reference substance name:
- Alkyl (C12-C14) glycidyl ether
- IUPAC Name:
- Alkyl (C12-C14) glycidyl ether
- Details on test material:
- Test Substance Identification: Alkyl (C12-C14) glycidyl ether; CAS RN 68609-97-02
Label Information: Epoxide 8 (Distilled C1214 Glycidyl Ether)
Purity and Composition: 51% C12 Glycidyl Ether
21% C14 Glycidyl Ether
5% C16 Glycidyl Ether
13% N + 1’s
4% Alpha Addition Products
94% total active (label claim)
Stability: Not provided
Date and Quantity Received: 29 Apr 05; 2471.2 gGW
Physical Description: Clear colorless liquid
Storage Conditions: Ambient
Constituent 1
Constituent 2
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Concentrations:
- saturated atmosphere (nominal concentration: 0.15 mg/l)
- No. of animals per sex per dose:
- 4
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 0.15 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: limited data
- Mortality:
- 0%
- Clinical signs:
- other: Moderate eye and nasal irritation was observed in all animals during the exposure
- Body weight:
- No adverse body weight changes
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The 7 hour LC50 is >0.15mg/l (a saturated atmosphere).
- Executive summary:
The exposure of 4 albino rats to the saturated atmosphere (nominal concentration 0.15 mg/l) for 7 hours at room temperature resulted in 100% survival. Moderate eye and nasal irritation was observed in all animals during the exposure.
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