Registration Dossier
Registration Dossier
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EC number: 219-553-6 | CAS number: 2461-15-6
Endpoint summary
Administrative data
Description of key information
Additional information
Study results have been available for read-across in respect of acute tests with fish, invertebrates and algae. The contents are summarised as below.
Fish acute toxicity test: The Rainbow trout static 96-Hour acute toxicity test of Alkyl (C12-C14) glycidyl ether is used for read-across to avoid duplicate tests. This study was performed according to the OECD guideline and used as a key study. Based on observation, the 96-hour median lethal concentration (LC50) of Alkyl glycidyl ether was determined to be >5’000 mg/l. The NOEC (No Observed Effect Concentration) for survival was determined to be <5’000 mg/l. 2-Ethylhexyl glycidyl ether (EC#:219-553 -6) is expected to have the similar property, thus its LC50 is greater than 5’000 mg/L and the NOEC is less than 5’000 mg/L.
Daphnia acute toxicity test: Based on the test results of Alkyl (C12-C14) glycidyl ether, EL50-48 h of 7.2 mg/L loading rate WAF with 95% confidence limits of 4.1 - 12 mg/L loading rate WAF and NOEL-48 h of 1.8 mg/L loading rate WAF were obtained. 2-Ethylhexyl glycidyl ether (EC#:219-553-6) is expected to have the similar property, thus its EL50-48h is 7.2 mg/L (95% CL: 4.1 -12 mg/L) and the NOEL-48h is 1.8 mg/L.
Alga growth inhibition test: Based on the test results of Alkyl (C12-C14) glycidyl ether, the test concentration that resulted in 50% inhibition (IC50) was determined to be 843.75 mg/L with 95 % confidence limits of 582.44-1097.71 mg/L, and the NOEC (No Observed Effect Concentration) was determined to be 500 mg/L. 2-Ethylhexyl glycidyl ether (EC#:219-553-6) is expected to have the similar property, thus its IC50 is 843.75 mg/L (95 % CL: 582.44 -1097.71 mg/L) and the NOEC is 500 mg/L.
The daphnia was most sensitive to 2-Ethylhexyl glycidyl ether. Thus, the EL50 of 7.2 mg/L was the key value for classification.
The biodegradation test with control is already available and showed the test substance has no toxicity to the bacteria. Thus, no more information is necessary for activated sludge respiration inhibition test and this study can be waived.
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