[[(2-ethylhexyl)oxy]methyl]oxirane

Endpoint summary

Description of key information

LD50(oral, rat, 24h): >5000 mg/kg bw;
LD0(dermal, rabbit, 72h): >4000mg/kg bw
LC50(inhalation, rat, 7h): >0.15 mg/L

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LC0

Value:

> 0.15 mg/L air

Physical form:

inhalation: mixture of gas and vapour

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

> 4 000 mg/kg bw

Additional information

An acute toxicity study (Dr. med. vet. W v Kobel, 1983) for the target substance was conducted by oral application following OECD guideline 401. Upon oral administration and a 14 day post-treatment observation period, the LD50 determined for test substance is greater than 5000 mg/kg bw. Twenty animals were administered at concentrations of 5’000 and 1’000 mg/kg bw. Dyspnoea, exophthalmus, ruffled fur and curved body position were seen, being common symptoms in acute test. In addition, the high dose animals showed sedation, tremor and ventral body position. However, lack of any clear dose-relation or adverse effects on body weight, gross pathological appearance indicated an absence of toxicity. Thus, it can be concluded that test substance exerts no toxic influence in rats of either sex at levels up to 5’000 mg/kg bw.

As the test material is a liquid with high boiling point (233 ±1 °C) and low vapour pressure (29 Pa at 25 °C), it is reasonable to expect that the inhalation route will not be an significant exposure route to the test material. An acute toxicity study by inhalation performed with a suitable surrogate substance dosed up to saturation concentration, exposing rats for 7 hours is available, confirming absence of acute toxicity by inhalation (LC0 > 0.15 mg/L) that can be used as read-across information to the target substance, as outlined.

For assessing acute toxicity via the dermal route a study for C12 -14 alkyl glycidyl ether exposed to rabbits is available, showing absence of mortality up to 4.5 ml/kg bw (equivalent to LD0 of ~4’000 mg/kg bw) which was the highest dose tested in this study. No mortality was seen in any of the dose groups tested.

Thus, it is justifiable to use these data for read across to 2-ethylhexyl glycidyl ether ,avoiding duplicate tests due to limited available information of target substance.

Justification for classification or non-classification

Based on the experimental results from oral, inhalation and dermal pathway, test substance is not to be classified according to CLP (Regulation EC No. 1272/2008) for acute toxicity.