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EC number: 220-165-4
CAS number: 2649-76-5
There are no data
available on aldonaethylenolether, but a GLP-guideline study to test the
mutagenic potential of aldona, the
pharmacological active metabolite of aldonaethylenolether,
in a bacterial reverse mutation assay (Ames test) was conducted. In this
study aldona did not show a mutagenic potential in the Salmonella
typhimurium strains TA 98, TA 100, TA 1538, TA 1535 and TA 1537 with and
without metabolic activation when tested up to the highest recommended
dose level of 5.0 mg/plate [Schering AG, Report No. X513 -draft-; 2000
-12 -05; OECD TG 471]. Therefore, also aldonaethylenolether, which will
be metabolized in vivo to the pharmacological active aldona,
can be expected to show no mutagenic potential.
Based on the study results a classification according to Directive
67/548/EEC and Regulation (EC) 1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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