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EC number: 220-165-4
CAS number: 2649-76-5
There are no data
available on aldonaethylenolether, but a GLP-guideline study to test the
eye irritating properties of aldona, the
pharmacological active metabolite of aldonaethylenolether,
was conducted. In this study the instillation of 0.1 g aldona into the
right eyes of 3 albino rabbits caused a slight to clear redness of the
conjunctivae in all three animals and a slight swelling of the
conjunctivae in one animal after one hour. 24 h after instillation no
signs of irritations were observed. The cornea and the iris were not
affected. According to EU classification criteria, aldona is not an
eye-irritant [Schering AG, Report No. A03230; 2001-02-26; OECD TG 405].
Since aldona is the pharmacological active metabolite of
aldonaethylenolether also aldonaethylenolether
can be expected to lead to the same effects as aldona.
application of 2000 mg/kg aldona to rats (3/sex) for 24 h in an acute
dermal toxicity study did not result in any skin alterations [Schering
AG, Report No. A03234; 2001-02-26]. Therefore, aldona can be regarded as
not skin-irritating. Since aldona is the pharmacological active
metabolite of aldonaethylenolether, also aldonaethylenolether can be
regarded as not skin-irritating.
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