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Description of key information

No internal acute toxicity studies of aldonaethylenolether are available. 
Results of an acute oral toxicity study are cited in RTECS database (Juli 2011):
Oral (rat): LD (lethal dose) > 3000 mg/kg
(Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third. Ave., New York, NY 10128) V.1- 1990- v. 1, p. 156, 1992 (ATDAEI))

Key value for chemical safety assessment

Additional information

Results of an acute toxicity study with aldonaethylenolether are cited in RTECS database (Juli 2011):

Oral application of aldonaethylenolether to rats results in LD > 3000 mg/kg [Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third. Ave., New York, NY 10128) V.1- 1990- v. 1, p. 156, 1992 (ATDAEI)]

Additionally, GLP-guideline studies with aldona, the pharmacological active metabolite of aldonaethylenolether, were conducted.

The single oral administration of aldona to male and female Wistar rats (3/sex) at the dose of 2000 mg/kg resulted in transient rough hair coat, apathy, squatting position, decreased body temperature only in females shortly after administration. No mortalities occurred and no compound-related macroscopic findings were seen. The LD50 was determined to be above 2000 mg/kg [Schering AG, Report No. A03235; 2001-02-26; OECD TG 423]

The single dermal application of aldona to rats (3/sex) for 24 hours (occlusively) did not induce any clinical or pathological signs. Again, the LD50 was determined to be above 2000 mg/kg [Schering AG, Report No. A03234; 2001-02-26; OECD TG 402].

Justification for classification or non-classification

Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP) is not required.