Registration Dossier
Registration Dossier
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EC number: 236-537-4 | CAS number: 13423-15-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
96 hr LC50: 1110 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 110 mg/L
Additional information
The acute toxicity of Tetrahydro-3-methylfuran to freshwater fish has been tested under a protocol equivalent or similar to the OECD 203 guideline method under static conditions with juvenile fathead minnows (Pimephales promelas) which yielded a 96 hour LC50 value of 1110 mg/L (DuPont, 1986). In addition, testing on a structural analog, tetrahydrofuran (CAS# 109-99-9), under similar conditions yieled 96 hour LC50 values of 2160 mg/L (Brooke, 1984) under flow-through conditions and 3,800 mg/L (DuPont, 1982) under static conditions; suggesting that tetrahydro-3-methylfuran is roughly 2 times more toxic than the analog substance. This is supported by QSAR modeling using U.S. EPA ECOSAR (v1.1) as demonstrated in the justification for read-across (INVISTA, 2012). Taken together, these data indicate that tetrahydro-3-methylfuran has a low degree of toxicity to freshwater fish.
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