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EC number: 200-680-0
CAS number: 68-19-9
This study was conducted in compliance with GLP of OECD. A total of 48
Sprague-Dawley rats was randomly assigned to receive, intraenously, 1,
5, 25 or 100 mg/kg of cyanocobalamin (6 males and 6 females in each
group) three times per week until completion of the study at 182 days
The animals were weekly examined and blood samples were taken at days 1,
85 and 182 for Cyanocobalamin determination.
Finally, all animals survived throughout the study period and had
similar growth rates. No evidence of toxicity was detected by a
detailed weekly examination of animals during the study period.
Therefore the NOAEL can be stablished at least at 100 mg/kg under the
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