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EC number: 200-680-0
CAS number: 68-19-9
A 16 -year-old female was referred for assessment of possible
anaphylactic reactions following cyanocobalamin injections. After the
first intramuscular injection she reported pain at the injection site.
In the second exposition, 2 months later, she also reported sensation of
subesternal burning and pleuritic pain. In the third exposition, 1 month
later, she added pruritus of the arms and legs.
Firstly she was skin tested to three commercial preparations of
injectable cyanocobalamin and to the benzyl alcohol (0.9%) preservative
found in each. Prick testing was negative, but intradermal testing was
positive in all cases.
Then, she was given a 500µg dose of a cyanocobalamin
gel (without benzyl alcohol) for intranasal application. The patient did
not demonstrated any reaction, and therefore Cyanocobalamin can be
considered as non sensitizer under the test conditions.
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