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EC number: 200-680-0
CAS number: 68-19-9
Supporting study: A 16 year-old-female was tested for skin sensitization to Cyanocobalamin. After having suffered diverse reactions to mixture of Cyanocobalamine plus benzyl alcohol, the patient did not showed any reaction to the intranasal application of 500µg of Cyanocobalamin alone.
Supporting study: A 16 -year-old female was referred for assessment of
possible anaphylactic reactions following Cyanocobalamin injections.
After the first intramuscular injection she reported pain at the
injection site. In the second exposition, 2 months later, she also
reported sensation of subesternal burning and pleuritic pain. In the
third exposition, 1 month later, she added pruritus of the arms and
legs. Firstly she was skin tested to three commercial preparations of
injectable cyanocobalamin and to the benzyl alcohol (0.9%) preservative
found in each. Prick testing was negative, but intradermal testing was
positive in all cases.
Then, she was given a 500µg dose of a cyanocobalamin
gel (without benzyl alcohol) for intranasal application. The patient did
not demonstrated any reaction, and therefore Cyanocobalamin can be
considered as non sensitizer under the test conditions.
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