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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 242-768-1 | CAS number: 19035-79-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 967
Materials and methods
- Objective of study:
- other: absorption, excretion, metabolism
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexadecan-1-ol
- EC Number:
- 253-149-0
- EC Name:
- Hexadecan-1-ol
- Cas Number:
- 36653-82-4
- Molecular formula:
- C16H34O
- IUPAC Name:
- hexadecan-1-ol
- Reference substance name:
- cetyl alcohol
- IUPAC Name:
- cetyl alcohol
- Test material form:
- other: solution
Constituent 1
Constituent 2
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 300 g
- Fasting period before study: no
- Diet, water: ad libitum a water solution of an acid hydrolysate of casein (2%), sucrose (7.6%), Wesson's salt mixture {0.4%), and water-soluble vitamins, starting the evening before the thoracic duct or the bile duct was cannulated
- Housing: During the lymph and bile collections, the rats were kept in restraining cages of the type described by BOLLMAN and supplied with the diet solution from an inverted bottle.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
- 0.2 mg [14C]cetyl alcohol and 300 mg [14C]cetyl alcohol. 0.2 mg and 300 mg [14C]cetyl alcohol were administered in 0.5 mL and 0.6 mL corn oil, respectively, by stomach tube . Each dose contained 1-1.5 µCi of 14C-radioactivity. - Duration and frequency of treatment / exposure:
- 24 or 48 hours
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.7 mg/kg bw (total dose)
- Dose / conc.:
- 1 000 mg/kg bw (total dose)
- No. of animals per sex per dose / concentration:
- 2 male rats. 1 rat per dose.
- Control animals:
- no
- Positive control reference chemical:
- No
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled : urine, faeces, lymph, bile, serum and various tissues
- Time and frequency of sampling:
- Other: Analytical methods: [I-14C]cetyl alcohol was obtained commercially and purified by thin-layer chromatography.
METABOLITE CHARACTERISATION STUDIES
- Method type(s) for identification: Thin layer chromatography of lipids
Results and discussion
- Preliminary studies:
- No
Main ADME results
- Type:
- absorption
- Results:
- Approximately 30-40 % of the [14C]-cetylalcohol administered dose are absorbed from the GIT after oral administration.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Systemically available.
- Details on distribution in tissues:
- About 30-40 % of the radioactivity were detected in urine, expired air, residual carcass, lymph and liver -> systemically distributed
- Details on excretion:
- 60 - 70 % in feces
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Triglycerides
Any other information on results incl. tables
- Cetyl alcohol was extensively (85%) converted (during lymphatic absorption) to saponifiable material which migrated (after methylation) with the normal fatty acid methyl esters and was presumed to be palmitic acid. The cetyl alcohol that was absorbed in non-saponifiable form was present largely in a complex that migrated ahead of the triglycerides.
Applicant's summary and conclusion
- Conclusions:
- Approximately 30-40% of the administered dose are absorbed from the GIT after oral administration. No radioactivity was detected in urine. Small amount of radioactivity were found in expired air (1-2%). The majority of the radioactivity is recovered in feces and intestine. Cetyl alcohol is most likely present in the animal body and is metabolized into its corresponding fatty acid which is then incorporated into triglycerides.
- Executive summary:
In the present study 14C-labeled cetyl alcohol (among other substances and mainly used for comparable measures) was administered by gastric intubation to rats in which the thoracic lymph duct had been cannulated. Radioactivity in the drained lymph and in the expired CO2 was determined periodically, and radioactivity (including radioactive metabolities) in the tissues was determined after 24 or 48 h. 14C-labelled cetyl alcohol was administered at a dose level of 0.7 and 1000 mg/kg bw in corn oil to rat and was found to be systemically available. About 30-40 % of the radioactivity were detected in urine, expired air, residual carcass, lymph and liver. Whereas the remaining 60-70 % were recovered from feces. Cetyl alcohol is most likely present in the animal body and is metabolized into its corresponding fatty acid which is then incorporated into triglycerides.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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