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EC number: 425-200-9 | CAS number: -
Table 1 Mortalility Data
Number of deaths in group of 5
5 to 15
The day indicated is the time that the animal was found dead.
A study was performed to assess the acute oral toxicity of Montaverdi to the rat. The method followed was based on that described in the EEC Methods for the determination of toxicity, Annex to Directive 92/69/EEC (OJ No. L383A, 29.12.92), Part B, Method B.1 Acute toxicity (oral). This study was also in compliance with the OECD Guideline for Testing of Chemicals No. 401 "Acute Oral Toxicity". Adopted: 24 February 1987. A group of ten fasted rats (five males and five females) received a single oral gavage dose of the test substance, as supplied, at a dose level of 2000 mg/kg bodyweight (the regulatory limit dose level). Of these animals, two males died during the study. Clinical signs of reaction to treatment included piloerection, hunched posture, waddling/unsteady gait, lethargy and abnormal faeces, seen in all rats. In addition, abnormal respiration, partially closed eyelids, pallid e).'tremities, walking on toes, increased salivation, abnormal urine, increased lacrimation, thin appearance, ungroomed appearance, prostration, blue/cold extremities and dull colouring to the eyes (pupils) were observed less commonly. Recovery was complete in all surviving animals by Day 6. A notably low weight gain was recorded for one female (No. 6) on Day 8 only. All other rats that survived treatment were considered to have achieved satisfactory bodyweight gains throughout the study. Macroscopic examination of decedents revealed congestive changes in a number of organs and tissues. There were no macroscopic abnormalities evident in any of the animals that survived treatment and were killed at study termination. As there were no mortality in any of the five females and only two deaths in the group of five males (2/10 total mortality), the results of the study demonstrate that the acute median lethal oral dose (LD50) to rats of Montaverdi is greater than 2000 mg/kg bodyweight.
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