Benzeneacetic acid, .alpha.-amino-4-hydroxy-, 2-hydroxyethyl ester, hydrochloride (1:1), (.alpha.R)-

Hydrolysis

Administrative data

Endpoint:

hydrolysis

Adequacy of study:

other information

Data source

Reference

Reference Type:

other:

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Results and discussion

Dissipation DT50 of parent compound

Dissipation DT50 of parent compound 1

pH:

4

Temp.:

40 °C

Hydrolysis rate constant:

16.31 s-1

DT50:

352.6 h

Dissipation DT50 of parent compound 2

pH:

4

Temp.:

50 °C

Hydrolysis rate constant:

36.58 s-1

DT50:

157.1 h

Dissipation DT50 of parent compound 3

pH:

4

Temp.:

60 °C

Hydrolysis rate constant:

65.84 s-1

DT50:

87.3 h

Dissipation DT50 of parent compound 4

pH:

7

Temp.:

40 °C

Hydrolysis rate constant:

1 542.78 s-1

DT50:

3.7 h

Dissipation DT50 of parent compound 5

pH:

7

Temp.:

50 °C

Hydrolysis rate constant:

2 996.78 s-1

DT50:

1.9 h

Dissipation DT50 of parent compound 6

pH:

7

Temp.:

60 °C

Hydrolysis rate constant:

6 896.3 s-1

DT50:

0.8 h