Registration Dossier
Registration Dossier
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EC number: 478-080-5 | CAS number: 57043-35-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The toxicokinetic study has not been performed. Instead, an assessment of toxicokinetic behaviour is submitted in accordance with the REACH Regulation. The assessment of the toxicokinetic behaviour is performed considering all the available data on the submission substance.
MAHP is mono-(2-acryloxyethyl) hexahydrophthalate. It is a liquid at room temperature, freezing at 7°C and boiling at 125°C. The substance is soluble in water (solubility 9.67 g/L). It has a log Pow of 1.66. It is stable at pH 4,7, and 10. Some test data have been 'read across' from the related substance MAES, 2-(acryloyloxy) ethyl hydrogen succinate. One possible hydrolysis product may be acrylic acid. Acrylic acid is also known to be harmful if swallowed and corrosive.
The toxicity information on MAHP indicates that the LD50 (rat, oral) is > 2500 mg/kg bw. It is also negative in the bacterial reverse mutation assay and micronucleus assay for genotoxicity. The remaining toxicity test results were from studies performed with the analogue MAES. It was corrosive in a conventional skin sensitisation assay. In the 28-day repeated dose study, effects were seen in the stomach (acanthosis/hyperkeratosis) at 150 and 300 mg/kg bw/d and, in males at all dose levels (15, 150 and 300 mg/kg bw/d), duodenum (mucosal hypertrophy). Systemic effects were only seen at 300 mg/kg bw/d, suggesting they were secondary to the effects at the site of administration (the stomach) due to the corrosive nature of the administered substance and/or hydrolysis products, and in the duodenum of males, possibly due to the corrosivity being enhanced as hydrolysis is speeded as the pH of the gastrointestinal tract content is raised. The similar effects of gastric irritation were observed in the reproduction/developmental toxicity screening test in rats for MAES.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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