Registration Dossier
Registration Dossier
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EC number: 442-680-5 | CAS number: 443688-20-8
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 12th to 14th, 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- EU Directive 92/69/EEC
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: shake flask and HPLC
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Red LF 6339
- IUPAC Name:
- Red LF 6339
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- < -4.2
- Temp.:
- 20 °C
- Remarks on result:
- other: .
Applicant's summary and conclusion
- Conclusions:
- Log Pow < -4.2
- Executive summary:
Neither the HPLC-method according to OECD Guideline No. 117 nor the flask-shaking method according to OECD Guideline No. 107 were applicable for the determination of the partition coefficient. Thus, the log Pow-value for the test item was estimated from its solubility in n-octanol and in water, respectively.
In the present study, the n-octanol solubility of the test item was determined to be < 5.375 g/1, which is below the smallest calibration point. No peak was detected at the relevant retention time. The water solubility of the test item was stated to be at least 170 g/1 (or above). The latter result was used for the calculation of the partition coefficient.
The partition coefficient, Log Pow, was calculated as < -4.2
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