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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
A reliable secondary source, summaring FEB pharmaco-toxicological properties, was used. However, the primary sources were not revisited in order to verify their contents; for this reason reliability score 2 was used. The used secondary source has been updated on September, 2013; therefore it covers the most updated literature on the substance.
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 5 540 mg/kg bw
Based on:
other: Diphenylacetic acid
Clinical signs:
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: ATAXIA
Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 on rat is 5540 mg/kg.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
A reliable secondary source, summaring FEB pharmaco-toxicological properties, was used. However, the primary sources were not revisited in order to verify their contents; for this reason reliability score 2 was used. The used secondary source has been updated on September, 2013; therefore it covers the most updated literature on the substance.
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no
Species:
mouse
Strain:
not specified
Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
-
Doses:
-
No. of animals per sex per dose:
-
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 400 mg/kg bw
Based on:
other: Diphenylacetic acid
Mortality:
-
Clinical signs:
-
Body weight:
-
Gross pathology:
-
Other findings:
-
Interpretation of results:
other: inconclusive
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The LD50 by subcutaneous route is 400 mg/kg.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed

Additional information

Justification for classification or non-classification

Acute oral toxicity

No data were found for FEB in the scientific literature. As a result of read-across with Diphenylacetic acid LD50 by oral route is 5540 mg/kg on rat. Therefore, data are inconclusive for classification.

Acute dermal toxicity

No data were found for FEB in the scientific literature. As a result of read-across with Diphenylacetic acid LD50 by subcutaneous route is 400 mg/kg. Overall, data are inconclusive to classify this endpoint.

STOT SE (Specific target organ toxicity - single)

No data were found for FEB in the scientific literature. As a result of the acute toxicity test for a structural analogue of FEB, the animals showed changes in motor activity and behavioral disorder as ataxia. Overall, these data are judged as conclusive but not sufficient for classification.