Registration Dossier
Registration Dossier
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EC number: 231-599-9 | CAS number: 7647-15-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Key study: Study well documented, meets generally accepted scientific principles, acceptable for assessment. The 22h-NOEC and EC50 in Vibrio fisheri were determined to be 4 and 5.7 g/L, respectively.
Supporting study: No guideline followed. No analytical monitoring of the test substance was made. The NOEC (0.3 days) for microorganism toxicity was determined to be 3.2 g/L.
Supporting study: No guideline followed. No analytical monitoring of the test substance was made. The NOEC (4 days) for microorganism toxicity was determined to be 3.2 g/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 5.7 g/L
- EC10 or NOEC for microorganisms:
- 4 g/L
Additional information
Key study: A Microtox chronic toxicity test was performed with the test substance sodium bromide on Vibrio fisheri organisms. The Microtox chronic toxicity test uses bacterial bioluminescence as the endpoint after a 22 -h incubation period. The inhibitory effects of chemicals influence the ability of the bacteria to produce luminescence, which is a combined function of cell division, metabolism, growth and luciferase induction. A toxic effect is expressed by a decrease in the luminescence intensity, induced by a depletion in cell metabolism. Each sample was tested with five concentrations, each in quadruplicate. The positive control was Copper(II) sulphate (pentahydrate). The 22h-NOEC and EC50 values were determined to be 4 and 5.7 g/L, respectively.
Supporting study: In the present microbial toxicity test, Pseudomonas fluorescens organisms were exposed at different concentrations of sodium bromide for 0.3 days in a static system. The evaluation parameter for fixing the NOEC was the specific growth rate. The NOEC for Pseudomonas fluorescens was stated to be 3.2 g/L.
Supporting study: In the present microbial toxicity test, Microcystis aeruginosa organisms were exposed at different concentrations of sodium bromide for 4 days in a static system. The evaluation parameter for fixing the NOEC was the specific growth rate. The NOEC for Microcystis aeruginosa was stated to be 3.2 g/L.
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