Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Data waiving:
other justification
Justification for data waiving:
other:

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
To assess the acute inhalational toxicity of 1,3:2,4-bis-O-(3,4-dimethylbenzylidene)-D-glucitol, a kinetic based calculation was done based on acute oral and dermal toxicity studies.

In conclusion, the extrapolated acute inhalation toxicity (4 h, LC50) of 1,3:2,4-bis-O-(3,4-dimethylbenzylidene)-D-glucitol was 11.15 mg/L for female and 12.2 mg/L for male.
Executive summary:

The extrapolation route to route could be performed to evaluate the inhalation toxicity of the test susbtance. The two oral and dermal acute toxicity studies available were limit tests performed at the highest possible test concentration. the results indicated no effects and no mortality. The inhalation route could be a possible route of exposure and the LC50 could be estimate based on dermal and oral toxicity studies. the LC50 values are 11.15 mg/L for female and 12.2 mg/L for male.