Registration Dossier
Registration Dossier
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EC number: 601-577-7 | CAS number: 118969-29-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 3-[(2E)-2-benzylidenehydrazino]-4-sulfonatobenzoate, disodium salt
- EC Number:
- 601-577-7
- Cas Number:
- 118969-29-2
- Molecular formula:
- C14H10N2Na2O5S
- IUPAC Name:
- 3-[(2E)-2-benzylidenehydrazino]-4-sulfonatobenzoate, disodium salt
- Test material form:
- other: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif:RAI f (SPF)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- distilled
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 males
5 females
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
Any other information on results incl. tables
Observations
Piloerection, hunched posture, and dyspnea were seen, being common symptoms in acute tests. Additionally, reduced locomotor activity and diarrhea was observed in all animals. The animals recovered within 6 days. At necropsy, no deviations from normal morphology were found in all animals.
Applicant's summary and conclusion
- Conclusions:
- No adverse effect observed with 2000mg/kg bw
- Executive summary:
No adverse effect observed with 2000mg/kg bw
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