Registration Dossier
Registration Dossier
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EC number: 601-577-7 | CAS number: 118969-29-2
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- 3-[(2E)-2-benzylidenehydrazino]-4-sulfonatobenzoate, disodium salt
- EC Number:
- 601-577-7
- Cas Number:
- 118969-29-2
- Molecular formula:
- C14H10N2Na2O5S
- IUPAC Name:
- 3-[(2E)-2-benzylidenehydrazino]-4-sulfonatobenzoate, disodium salt
- Test material form:
- other: solid
- Details on test material:
- Purity 59.2 %
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Pirbright White Strain (Tif:DHP)
- Sex:
- male/female
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: vaseline
- No. of animals per dose:
- The test was performed on 10 male and 10 female guinea pigs in
the test group and 5 males and 5 females in the control group - Details on study design:
- The induction was a two-stage operation. First, intradermal
injections (into the neck region); second, closed patch exposure
over the injection sites one week later. - Challenge controls:
- A control group of 10 animals (5 m/5 f) was treated with adjuvant
and the vehicle during the induction period.
Results and discussion
Any other information on results incl. tables
Number of positive animals per group after occlusive epidermal application
|
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- sensitising
- Executive summary:
sensitising
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