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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicity
Author:
SIDS OECD 2004
Year:
2004
Bibliographic source:
SIDS OECD 2004
Report date:
2004

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3-hydroxy-2-naphthoic acid
EC Number:
202-180-8
EC Name:
3-hydroxy-2-naphthoic acid
Cas Number:
92-70-6
Molecular formula:
C11H8O3
IUPAC Name:
3-hydroxy-2-naphthoic acid

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 823 - <= 1 040 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral LD50 in rat was between 823-1040 mg/kg bw. Clinical signs included reduced
activity, accelerated breathing, closure of eyes, and diarrhea. Gastro-intestinal irritation and dark or
mottled livers were seen in the animals that had died during the studies.

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